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Product Details:
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| Name: | Geneticin | CAS: | 108321-42-2 |
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| Form: | Powder | Color: | White To Off-white |
| Storage Temp.: | 2-8°C | Sample: | Available |
| High Light: | Geneticin G 418 Disulfate Salt,G 418 Disulfate Salt,CAS 108321-42-2 |
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CAS 108321-42-2 Geneticin G418 Disulfate Salt Antibiotic Raw Materials
| Geneticin Basic information |
| Product Name: | Geneticin |
| CAS: | 108321-42-2 |
| MF: | C20H42N4O14S |
| MW: | 594.63 |
| EINECS: | 600-864-4 |
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General description |
G-418 is an aminoglycoside antibiotic, which is produced by Micromonospora rhodorangea NRRL 5326 strain. It has a broad range of antibacterial activity both in vivo and in vitro. It also shows activity against protozoa, cecal amoebiasis, and helminthes. It is commonly known as geneticin selective antibiotic. |
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| Geneticin Chemical Properties |
| storage temp. | 2-8°C |
| solubility | H2O: 50 mg/mL |
| form | white powder |
| color | white to off-white |
| optical activity | [α]/D (Specific Rotation: +104.4o (c=0.3% in H2O at 26oC)) |
| Water Solubility | soluble |
| InChIKey | QNQZPJLBGRQFDD-ZLRXUJDMSA-N |
| Safety Information |
| Hazard Codes | Xn,Xi |
| Risk Statements | 20/21/22-36/37/38-42/43 |
| Safety Statements | 22-24/25-36/37-23-36-26-45 |
| WGK Germany | 3 |
| RTECS | CB9378500 |
| HS Code | 29419090 |
Application
G418 disulfate salt is an aminoglycoside antibiotic similar in structure to gentamicin used for selection and maintenance of prokaryotic and eukaryotic cells transfected with a iNOS promoter construct and neomycin resistance gene†. Optimal concentrations for selection and maintenance vary by cell lines. Bacteria and algae require 5 μg/mL or less while animal cells may require 300-500 μg/mL.
Biochem/physiol Actions
G-418 inhibits protein synthesis at the early stages of elongation, post-initiation, at the initiation stage of translation as well as just before the initiation stage of translation.
Caution
The product is stable for two years when stored at 2-8°C. Stock solutions are stable at 37°C for 8 days.
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